Using mathematics to treat diabetes
   ...five minutes at a time


Human closed-loop blood glucose control studies

Autonomous and Continuous Adaptation of a Bihormonal Bionic Pancreas in Adults and Adolescents with Type 1 Diabetes.

Journal of Clinical Endocrinology and Metabolism, 2014. PDF

Supplemental online material. PDF

 Blood Glucose Control in Type 1 Diabetes With a Bihormonal Bionic
 Endocrine Pancreas.

Diabetes Care, 2012. PDF
 Supplemental online material. PDF

 A Bihormonal Closed-Loop Artificial Pancreas for Type 1 Diabetes.

 Science Translational Medicine, 2010. PDF

 Supplemental online material. PDF

Efficacy Determinants of Subcutaneous Microdose Glucagon During Closed-Loop Control.
J. Diabetes Science and Technology, 2010. PDF (includes appendix)

CGM comparison studies

 Comparative Effectiveness Analysis of Three Continuous Glucose Monitors.

es Care, 2013. PDF (includes supplement)

Preclinical closed-loop blood glucose control studies

A Feasibility Study of Bihormonal Closed-Loop Blood Glucose Control Using Dual Subcutaneous Infusion of Insulin and Glucagon in Ambulatory Diabetic Swine.
J. Diabetes Science and Technology, 2009. 

Adaptive Closed-Loop Control Provides Blood-Glucose Regulation Using Dual Subcutaneous Insulin and Glucagon Infusion in Diabetic Swine.
J. Diabetes Science and Technology, 2007. 

Pharmacodynamics and Stability of Subcutaneously Infused Glucagon in a Type 1 Diabetic Swine Model In Vivo. 
J. Diabetes Science and Technology, 2007. 
Review and commentary

Continuous Glucose Monitoring Awaits Its “Killer App”.
J. Diabetes Science and Technology, 2008.