Using mathematics to treat diabetes



                                       
   ...five minutes at a time



Publications

Human closed-loop blood glucose control studies

Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes

New England Journal of Medicine, 2014. PDF

Supplemental online material. PDF




Autonomous and Continuous Adaptation of a Bihormonal Bionic Pancreas in Adults and Adolescents with Type 1 Diabetes.
  

J. Clinical Endocrinology and Metabolism, 2014. PDF

Supplemental online material. PDF


 Blood Glucose Control in Type 1 Diabetes With a Bihormonal Bionic
 Endocrine Pancreas.

 Diabetes Care, 2012. PDF
 
 Supplemental online material. PDF


 A Bihormonal Closed-Loop Artificial Pancreas for Type 1 Diabetes.

 Science Translational Medicine, 2010. PDF

 Supplemental online material. PDF
 



Efficacy Determinants of Subcutaneous Microdose Glucagon During Closed-Loop Control.
J. Diabetes Science and Technology, 2010. PDF (includes appendix)

CGM comparison studies

A Comparative Effectiveness Analysis of Three Continuous Glucose Monitors: The Navigator, G4 Platinum, and Enlite

J. Diabetes Science and Technology, 2014. PDF




Comparative Effectiveness Analysis of Three Continuous Glucose Monitors.

Diabet
es Care, 2013. PDF (includes supplement)



Preclinical closed-loop blood glucose control studies

A Feasibility Study of Bihormonal Closed-Loop Blood Glucose Control Using Dual Subcutaneous Infusion of Insulin and Glucagon in Ambulatory Diabetic Swine.
 
J. Diabetes Science and Technology, 2009. 
PDF

Adaptive Closed-Loop Control Provides Blood-Glucose Regulation Using Dual Subcutaneous Insulin and Glucagon Infusion in Diabetic Swine.
J. Diabetes Science and Technology, 2007. 
PDF

Pharmacodynamics and Stability of Subcutaneously Infused Glucagon in a Type 1 Diabetic Swine Model In Vivo. 
Diabetes Technology and Therapeutics, 2007. 
PDF
Review and commentary

Continuous Glucose Monitoring Awaits Its “Killer App”.
J. Diabetes Science and Technology, 2008. 
PDF