Using mathematics to treat diabetes
                                       
   ...five minutes at a time

Publications

Human closed-loop blood glucose control studies

Autonomous and Continuous Adaptation of a Bihormonal Bionic Pancreas in Adults and Adolescents with Type 1 Diabetes.

Journal of Clinical Endocrinology and Metabolism, 2014. PDF

Supplemental online material. PDF

 Blood Glucose Control in Type 1 Diabetes With a Bihormonal Bionic
 Endocrine Pancreas.

 
Diabetes Care, 2012. PDF
 
 Supplemental online material. PDF


 A Bihormonal Closed-Loop Artificial Pancreas for Type 1 Diabetes.

 Science Translational Medicine, 2010. PDF

 Supplemental online material. PDF
 



Efficacy Determinants of Subcutaneous Microdose Glucagon During Closed-Loop Control.
J. Diabetes Science and Technology, 2010. PDF (includes appendix)


CGM comparison studies

 Comparative Effectiveness Analysis of Three Continuous Glucose Monitors.

 Diabet
es Care, 2013. PDF (includes supplement)



Preclinical closed-loop blood glucose control studies

A Feasibility Study of Bihormonal Closed-Loop Blood Glucose Control Using Dual Subcutaneous Infusion of Insulin and Glucagon in Ambulatory Diabetic Swine.
 
J. Diabetes Science and Technology, 2009. 
PDF

Adaptive Closed-Loop Control Provides Blood-Glucose Regulation Using Dual Subcutaneous Insulin and Glucagon Infusion in Diabetic Swine.
J. Diabetes Science and Technology, 2007. 
PDF

Pharmacodynamics and Stability of Subcutaneously Infused Glucagon in a Type 1 Diabetic Swine Model In Vivo. 
J. Diabetes Science and Technology, 2007. 
PDF
Review and commentary

Continuous Glucose Monitoring Awaits Its “Killer App”.
J. Diabetes Science and Technology, 2008. 
PDF