Using mathematics to treat diabetes
   ...five minutes at a time

We look forward to a cure for type 1 diabetes.

Until this is achieved, we are developing and testing technology to reduce the impact of diabetes on those who live with it every day.

We are a collaborative group from Boston University and Massachusetts General Hospital working together to make automated blood glucose control a reality. Engineers from Boston University have developed a closed-loop bionic pancreas system that uses continuous glucose monitoring along with subcutaneous delivery of both rapid-acting insulin (to lower blood glucose) and glucagon (to raise blood glucose) as directed by a computer algorithm. The bionic pancreas automatically makes a new decision about insulin and glucagon dosing every five minutes. The system is being tested in people with type 1 diabetes at Massachusetts General Hospital (see Publications and Clinical Trials).

Achieving and maintaining near-normal blood glucose concentrations are critical for the long-term health of people with diabetes. Unfortunately, the therapy required to achieve this goal is extremely demanding, requiring frequent blood glucose checks and either multiple daily insulin injections or the use of an insulin pump. Even with current state-of-the-art insulin replacement, it is almost impossible to completely avoid hyperglycemia and hypoglycemia.

The development of a drug delivery device that responds to glucose concentrations to automatically avoid both high and low blood glucose, a bionic endocrine pancreas, has been a long-term goal of diabetes therapy. Although it is well known that people with diabetes do not make enough insulin, it is also true that their pancreas does not release glucagon, a blood glucose-raising hormone, in response to hypoglycemia. Previous bionic pancreas designs did not include the capability to administer glucagon.